Principles for modelling dose-response for the risk assessment of chemicals / first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals.
Material type:
TextSeries: Environmental health criteria ; 239.Publication details: Geneva, Switzerland : World Health Organization, c2009.Description: xx, 137 p. : ill. (some col.), charts ; 21 cmISBN: - 9789241572392
- 9241572396
- 20 362.102 500417
- Also available online.
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University College of Medicine Library Shelf No. 23, LBS | Not for loan and check out is restricted | 362.102 WHO-E 2009 500417 (Browse shelf(Opens below)) | Not For Loan (Restricted Access) | 500417 |
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| 362.1 WOR-W 2004 504522 The world health report 2004\ | 362.1 WRI-D 1979 500787 Dr. Wright's book of nutritional therapy : | 362.1 YOU-S 1970 500783 You and your health | 362.102 WHO-E 2009 500417 Principles for modelling dose-response for the risk assessment of chemicals / | 362.1023 MAC-P 1995 500809 The meaning and challenge of primary health care / | 362.1023 PRI-F 1997 500814 Primary health care of children / | 362.1042 HEL-C 2000 500815 Culture, health, and illness / |
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
Includes bibliographical references (p. 103-110).
Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations.
This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description.
Also available online.