Thermodynamic theory of site-specific binding processes in biological macromolecules / Enrico Di Cera.

By:

Di Cera, Enrico

Material type: Text

TextPublication details: New York : Cambridge University Press, 1995.Description: xvi, 296 p. : ill. ; 26 cmISBN:

0521416590 (hc)

Subject(s):

DDC classification:

612.015 20 CER-T 1995 502075

Contents:

1. Statistical thermodynamic foundations -- 2. Global binding processes -- 3. Local binding processes -- 4. Specific cases and applications -- 5. Site-specific effects in Ising networks.

Summary: This book provides the first systematic treatment of the thermodynamic theory of site-specific effects in biological macromolecules. It describes the phenomenological and conceptual bases required to allow a mechanistic understanding of these effects from analysis of experimental data.Summary: The thermodynamic theory also results in novel experimental strategies that enable the derivation of information on local, site-specific properties of a macromolecular system from analysis of perturbed global properties. The treatment focuses on binding phenomena, but is amenable to extension both conceptually and formally to the analysis of other cooperative processes, such as protein folding and helix-coil transitions.Summary: Much attention is devoted to the analysis of mutational perturbations used as probes of site-specific energetics. The arrangement of various sections in the book allows its use both as a reference work on cooperative binding phenomena for any scientist involved in structure-function studies of biological macromolecules, and as a text for graduate students in biochemistry and biophysics.

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Holdings ( 1 )
Title notes ( 5 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode	Item holds
Reference	University College of Medicine Library Shelf No. 42, LBS	Not for loan and check out is restricted	612.015 CER-T 1995 502075 (Browse shelf(Opens below))	Not For Loan (Restricted Access)		502075

Total holds: 0

Includes bibliographical references.

1. Statistical thermodynamic foundations -- 2. Global binding processes -- 3. Local binding processes -- 4. Specific cases and applications -- 5. Site-specific effects in Ising networks.

This book provides the first systematic treatment of the thermodynamic theory of site-specific effects in biological macromolecules. It describes the phenomenological and conceptual bases required to allow a mechanistic understanding of these effects from analysis of experimental data.

The thermodynamic theory also results in novel experimental strategies that enable the derivation of information on local, site-specific properties of a macromolecular system from analysis of perturbed global properties. The treatment focuses on binding phenomena, but is amenable to extension both conceptually and formally to the analysis of other cooperative processes, such as protein folding and helix-coil transitions.

Much attention is devoted to the analysis of mutational perturbations used as probes of site-specific energetics. The arrangement of various sections in the book allows its use both as a reference work on cooperative binding phenomena for any scientist involved in structure-function studies of biological macromolecules, and as a text for graduate students in biochemistry and biophysics.